{"id":772,"date":"2022-07-31T18:52:42","date_gmt":"2022-07-31T23:52:42","guid":{"rendered":"https:\/\/blogs.und.edu\/crc-news\/?p=772"},"modified":"2022-08-18T15:23:53","modified_gmt":"2022-08-18T20:23:53","slug":"ariscience-collaboration-on-sars-cov-2-research","status":"publish","type":"post","link":"https:\/\/blogs.und.edu\/crc-news\/2022\/07\/ariscience-collaboration-on-sars-cov-2-research\/","title":{"rendered":"ARISCIENCE Collaboration on SARS-CoV-2 Research"},"content":{"rendered":"\r\n<p class=\"wp-block-paragraph\">On August 6, 2020 <a href=\"https:\/\/www.ariscience.com\" target=\"_blank\" rel=\"noreferrer noopener\">ARIScience<\/a> and the University of North Dakota signed a research collaboration agreement on the use of the UND Computational Research Center\u2019s (UND CRC) high performance computing (HPC) system to further ARIScience\u2019s SARS-CoV-2 protein interruption research. As part of the collaboration ARIScience will used UND CRC\u2019s Talon HPC cluster and exchanged information with UND on efficient use of HPC to advance biological research.<\/p>\r\n\r\n\r\n\r\n<p class=\"wp-block-paragraph\">&#8220;Massachusetts-based biotech company called ARIScience has used supercomputers to identify existing drugs able to break up SARS-CoV-2 \u2013 the virus that causes COVID-19 \u2013 at the molecular level. Thanks to computer simulations, followed by validation through statistical analysis on a 1.5MM patient dataset, the researchers have found four FDA-approved drugs that could be repurposed for COVID-19.<\/p>\r\n\r\n\r\n\r\n<p class=\"wp-block-paragraph\">These drugs are Metformin, Hydrochlorothiazide, Triamcinolone and Amoxicillin. They could reduce COVID-19 mortality odds by 25 percent, says the lead researcher, Joy Alamgir. The results are currently undergoing a peer review process.<\/p>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/protein-interaction-small.png\"><img loading=\"lazy\" decoding=\"async\" width=\"384\" height=\"395\" class=\"wp-image-774\" src=\"https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/protein-interaction-small.png\" alt=\"\" srcset=\"https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/protein-interaction-small.png 384w, https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/protein-interaction-small-292x300.png 292w\" sizes=\"auto, (max-width: 384px) 100vw, 384px\" \/><\/a>\r\n<figcaption>QQ Simulation of Protein Interaction<\/figcaption>\r\n<\/figure>\r\n\r\n\r\n\r\n<p class=\"wp-block-paragraph\">While the researchers started by using their own supercomputing cluster, they quickly realized that they needed additional computing resources. They then applied for extra resources via the COVID-19 HPC Consortium \u2013 and were granted access to the Texas Advanced Computing Center (TACC) and Pittsburgh Supercomputing Center (PSC).<\/p>\r\n\r\n\r\n\r\n<p class=\"wp-block-paragraph\">Separately they requested access to University of North Dakota, the University of Maine System and Massachusetts Green High Performance Computing Center (MGHPCC) centers \u2013 all of whom granted access to their supercomputing systems. &#8216;We would not have completed the simulations ourselves, just because of the sheer computing power needed by our novel algorithms,&#8217; says Alamgir.&#8221;<\/p>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/stats.png\"><img loading=\"lazy\" decoding=\"async\" width=\"448\" height=\"232\" class=\"wp-image-773\" src=\"https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/stats.png\" alt=\"\" srcset=\"https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/stats.png 448w, https:\/\/blogs.und.edu\/crc-news\/wp-content\/uploads\/sites\/34\/2022\/07\/stats-300x155.png 300w\" sizes=\"auto, (max-width: 448px) 100vw, 448px\" \/><\/a>\r\n<figcaption>Bio-informatics Statistical Analysis<\/figcaption>\r\n<\/figure>\r\n","protected":false},"excerpt":{"rendered":"<p>On August 6, 2020 ARIScience and the University of North Dakota signed a research collaboration agreement on the use of the UND Computational Research Center\u2019s (UND CRC) high performance computing (HPC) system to further ARIScience\u2019s SARS-CoV-2 protein interruption research. As part of the collaboration ARIScience will used UND CRC\u2019s Talon HPC cluster and exchanged information [&hellip;]<\/p>\n","protected":false},"author":106,"featured_media":774,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[259],"tags":[250],"class_list":["post-772","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-collab-outreach","tag-talon"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ARISCIENCE Collaboration on SARS-CoV-2 Research - Computational Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.und.edu\/crc-news\/2022\/07\/ariscience-collaboration-on-sars-cov-2-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ARISCIENCE Collaboration on SARS-CoV-2 Research - Computational Research Center\" \/>\n<meta property=\"og:description\" content=\"On August 6, 2020 ARIScience and the University of North Dakota signed a research collaboration agreement on the use of the UND Computational Research Center\u2019s (UND CRC) high performance computing (HPC) system to further ARIScience\u2019s SARS-CoV-2 protein interruption research. As part of the collaboration ARIScience will used UND CRC\u2019s Talon HPC cluster and exchanged information [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.und.edu\/crc-news\/2022\/07\/ariscience-collaboration-on-sars-cov-2-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Computational Research Center\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-31T23:52:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-18T20:23:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.und.edu\/crc-news\/\/srv\/htdocs\/wp-content\/uploads\/sites\/38\/2022\/07\/protein-interaction-small.png\" \/>\n\t<meta property=\"og:image:width\" content=\"384\" \/>\n\t<meta property=\"og:image:height\" content=\"395\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"dapostal\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"dapostal\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.und.edu\\\/crc-news\\\/2022\\\/07\\\/ariscience-collaboration-on-sars-cov-2-research\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.und.edu\\\/crc-news\\\/2022\\\/07\\\/ariscience-collaboration-on-sars-cov-2-research\\\/\"},\"author\":{\"name\":\"dapostal\",\"@id\":\"https:\\\/\\\/blogs.und.edu\\\/crc-news\\\/#\\\/schema\\\/person\\\/2ad399264c3d45ea5e509624317bc2ec\"},\"headline\":\"ARISCIENCE Collaboration on SARS-CoV-2 Research\",\"datePublished\":\"2022-07-31T23:52:42+00:00\",\"dateModified\":\"2022-08-18T20:23:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.und.edu\\\/crc-news\\\/2022\\\/07\\\/ariscience-collaboration-on-sars-cov-2-research\\\/\"},\"wordCount\":265,\"image\":{\"@id\":\"https:\\\/\\\/blogs.und.edu\\\/crc-news\\\/2022\\\/07\\\/ariscience-collaboration-on-sars-cov-2-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.und.edu\\\/crc-news\\\/wp-content\\\/uploads\\\/sites\\\/34\\\/2022\\\/07\\\/protein-interaction-small.png\",\"keywords\":[\"Talon\"],\"articleSection\":[\"Collaboration &amp; 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